FÃƒÂ¼llbeck M, Michalsky E, Dunkel M, Preissner R. Natural products: sources and databases. Highlight Nat. Prod. Rep. 2006 April 10; 23, 347 - 356, DOI: 10.1039/b513504b
This Highlight gives a general survey of natural product databases, suppliers and manufacturers. It describes opportunities for researchers to obtain information about natural compounds and makes a proposal for successful identification of pharmaceutically relevant substances.
Authors offer extensive research and market Ã¢â‚¬Å“leadsÃ¢â‚¬Â for those interested in nature-derived bio-material. The article, once again, stresses yet untapped potential of diverse natural sources that offer superior quality of discovery leads. Ã¢â‚¬Å“It is supposed that only 5-15% of approximately 250,000 species of higher plants have been investigated for the presence of bioactive compoundsÃ¢â‚¬Â. Despite this low percentage, Ã¢â‚¬Å“about half of all compounds that were successful in clinical trials during the past 20 years have at least been derived from natural originÃ¢â‚¬Â.
Not to disregard widespread application of combinatorial chemistry, nature-derived compounds have this unique perfect natural fit. Ã¢â‚¬Å“The rise of combinatorial chemistry reduced the interest in natural compounds among pharmaceutical companies. However, not all promises of high-throughput synthesis were kept, because the produced compounds that are drug-like in size and properties have not evolved to interact with biomolecules and may therefore induce unexpected and possibly severe side effectsÃ¢â‚¬Â. Natural compounds are not only a time-proven must in screening assays, but they also provide inspirational material for building blocks and scaffolds.