NDL - Natural Derivatives Library
NDL-3000 elaborates on structural variety of pure natural compounds and includes synthetic compounds and synthetically modified pure natural compounds: alkaloids, natural phenols, nucleoside analogs, carbohydrates, purines, pyrimidines, flavonoids, steroidal compounds, and natural amino acids. The list is incomplete.
NDL-3000 would be “natural” extension of well-known NPL-640, Library of Pure Natural compounds , in design and structural diversity.
Compounds comply with screening purity standards. NDL-3000 is available as a collection of 3000 compounds, individual compounds, and/or in smaller subsets. Custom formatting in vials, 96/384 plates, is always welcomed.
Structural data and pricing information is available on request. Contact us now!
Receive a copy of any of TimTec compounds collections on a CDRom - please e-mail your exact postal address.
Natural Products in Journal of Medicinal Chemistry
One of the latest Miniperspectives of Journal of Medicinal Chemistry examines the benefits of paring of natural products chemistry and synthetic organic chemistry: “A combination of natural products chemistry and focused library synthesis furnishes a powerful tool for drug discovery”.
Ojuma, I. Modern Natural Products Chemistry and Drug Discovery. J.Med.Chem. 2008, 51, 9, 2587-2588.
The paramount importance of nature-sourced and -inspired products in drug discovery is proverbial. Statistics keeps exploring and screening natural products and their derivatives topical: combinatorial chemistry produced only one FDA-approved drug for the last 20 years compared to 57.7% of approvals for natural-products-based drugs.
At the same time evolution in combinatorial chemistry, parallel synthesis, computational chemistry, and molecular target-based drug discovery accumulated valuable methods and tools that can be applied to natural material.
Another work investigates paring of natural products chemistry and synthetic organic chemistry in greater details following successful drug discovery examples in pharmaceutical industry:
Newman, D. J. Natural products as leads to potential drugs: an old process or the new hope for drug discovery? J.Med.Chem. 2008, 51, 9, 2587-2588.
Following discovery trends, TimTec NDL-3,000, Natural Products Derivatives Library of 3,000 compounds, is a cross-over between pure nature molecules and synthetic organic chemistry. NDL-3,000 elaborates on structural diversity of pure natural compounds including natural derivatives, analogs, semi-natural compounds, and mimics.
