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Flavonoid Derivatives


Flavonoids make one of the most preferred groups of natural chemotypes tested for various biological activities. Flavonoids have low toxicity and are widely available in plants including edible. 

This group of compounds provides a good example of "natural" holding leading performance in anti-inflammatory, anticancer, anti-oxidant activities.

9 core Flavonoid structures are used to assemble TimTec small collection of 500 Flavonoids Derivatives.
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Chalcone Flavanone Flavone
Dihydroflavonol  Flavonol  Flavan
 Stilbene  Isoflavonoid  Neoflavonoid

Download TimTec small collection of 500 Flavonoids Derivatives

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Following the screens of TimTec compounds and compound collections involving flavonoids:

Holder S., et al., Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase. Mol Cancer Ther. Jan. 2007, 6(1), 163-172

Bullock A.N., et al. Structural Basis of Inhibitor Specificity of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM-1) Kinase. J. Med. Chem., 2005, 48 (24), pp 7604–7614

Auld, D. S., Characterization of Chemical Libraries for Luciferase Inhibitory Activity. J. Med. Chem., 2008, 51 (8), pp 2372–2386

 

Selected references highlighting flavonoids therapeutic benefits:

Cushnie TP, Lamb AJ. Recent advances in understanding the antibacterial properties of flavonoids. Int J Antimicrob Agents. 2011 Aug;38(2):99-107.

Nishiumi S, Miyamoto S, et.al. Dietary flavonoids as cancer-preventive and therapeutic biofactors.Front Biosci (Schol Ed). 2011 Jun 1;3:1332-62.

González R, Ballester I, et.al. Effects of flavonoids and other polyphenols on inflammation.Crit Rev Food Sci Nutr. 2011 Apr;51(4):331-62.

 

gossypol

BioActive Scroller

ST096084 Nateglinide

ST096084 Nateglinide

Formula: C19H27NO3MW: 317.43CAS: 105816-04-4MDL NUMBER: MFCD00875706Smiles: CC(C)C1CCC(CC1)C(=O)NC(C..
ST096085 Flupirtine maleate

ST096085 Flupirtine maleate

Formula: C19H21FN4O6MW: 420.4CAS: 75507-68-5MDL NUMBER: MFCD00941415Smiles: OC(=O)/C=C/C(O)=O.CCOC(=..
ST096086 Flibanserin

ST096086 Flibanserin

Formula: C20H21F3N4OMW: 390.41CAS: 167933-07-5MDL NUMBER: MFCD00918402Smiles: FC(F)(F)c1ccc(cc1)N1CC..