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Monastrol (ST075209) Cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC50=14Ã‚ÂµM) by binding to the mitotic kinesin Eg5.
Genipin (ST080860) Genipin is an aglycone derived from an iridoid glycoside called geniposide present in fruit of Gardenia jasmindides Ellis. Genipin is an excellent natural cross-linker for proteins, collagen, gelatin, and chitosan cross-linking.
Melitten is basic polypeptide from the venom of the honey bee (Apis mellifera); it contains 62 amino acids, has cytolytic properties, causes contracture of muscle, releases histamine and disrupts surface tension, probably due to lysis of cell and mitochondrial membranes.
Anabasine Hydrochloride (ST069297)
Insecticide Biomarker Inhibitors of breast cancer aromatase VET: anabasin hydrochloride has no teratogenic properties VET: inhibited rat adrenal mitochondrial 11 beta-hydroxylase and microsomal 21-hydroxylase
Potent ligand for many nAChR subtypes. Known for analgesic, antihypertensive and inotropic activities. partial agonist of high-affinity nicotinic acetylcholine receptors
Exhibits multiple biological effects including antifertility and anticancer activity.
Vasorelaxing agent acting mainly by antagonism at 5-HT (2A) receptors Toxic to cells, may play defensive role in plants
Possesses antiplasmodial activity associated with a low cytotoxicity Monoamine oxidase (MAO) inhibitor inhibit HIV replication in H9 lymphocyte cells Antibiotic
Sedative, hemostatic, hypotensitive effects
Initiates tumor and shows clastogenic activity in mice
Antialcoholic affect: reduces aethanol anesthesia
Competitive inhibitor of catechol-O-methyltransferase Stereoselective competitive inhibitor of the enzyme monoamine oxidase
Antiinflammatory activity Steroidal alkaloid solasodine is linked to impaired female sexual behavior of rat offspring Antiproliferative activities against human colon (HT29) and liver (HepG2) cancer cells