MW: 420.4

CAS: 75507-68-5

MDL NUMBER: MFCD00941415

Smiles: OC(=O)/C=C/C(O)=O.CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)nc1N

THERAPEUTIC CATEGORY: Flupirtine, an aminopyridine is a centrally acting nonopioid analgesic. It is available in Europe since 1984 and sold mainly under the names Katadolon, Trancolong and Metanor. It is unique as an non-opioid, non-NSAID, non-steroidal analgesic.

ACCEPTORS: 6

DONORS: 6

ROTATION BONDS: 7

N+O: 10

Chiral Centers: 0

LogP: 3.19

LogS: -4.18

LIPINSKI: 3

Synonyms: ethyl 2-amino-6-[(4-fluorobenzyl)amino]pyridine-3-carbamate compound with maleic acid (1:1);FLUPIRTINE MALEATE;2-AMINO-6-[[(4-FLUOROPHENYL)METHYL]AMINO]-3-PYRIDINYL]-CARBAMIC ACID, ETHYL ESTER MALEATE;Flupirtinemaleatelupirtine;Ethyl-2-amino-6-[(4-fluorbenzyl)amino]pyridin-3-carbamat, Verbindung mit Maleinsure (1:1);Keiton;Ketadolon;N-[2-Amino-6-[[4-fluorophenyl)methyl]amino]-3-pyridinyl]carbamicacidethylestermaleate

CAS:75507-68-5

MF:C15H17FN4O2.C4H4O4

MW:420.4

EINECS:278-225-0

Product Categories:Other Potassium channel modulators;APIS Flupirtine maleate

Chemical Properties: storage temp. 2-8C

Safety Information: Safety Statements 22-24/25 Flupirtine maleate

Usage And Synthesis: Biological ActivityNon-opioid analgesic with muscle relaxant properties. Activates K + channels and indirectly antagonizes NMDA receptors. Exhibits neuroprotective actions in a model of cerebral ischemia in mice and reduces apoptosis and necrosis induced by noxious stimuli. Flupirtine maleate

MW: 390.41

CAS: 167933-07-5

MDL NUMBER: MFCD00918402

Smiles: FC(F)(F)c1ccc(cc1)N1CCN(CCn2c(=O)[nH]c3ccccc23)CC1

THERAPEUTIC CATEGORY: Flibanserin (code name BIMT-17; proposed trade name Girosa) is a drug that is currently being investigated by Boehringer Ingelheim as a novel, non-hormonal treatment for pre-menopausal women with Hypoactive Sexual Desire Disorder (HSDD).[1][2] HSDD is the most commonly reported female sexual complaint and characterized by a decrease in sexual desire that causes marked personal distress and/or personal difficulties. According to prevalence studies about 1 in 10 women reported low sexual desire with associated distress, which may be HSDD.[3] The neurobiological pathway of female sexual desire involves interactions among multiple neurotransmitters, sex hormones and various psychosocial factors. Sexual desire is modulated in distinct brain areas by a balance between inhibitory and excitatory neurotransmitters, serotonine acting as an inhibitor while dopamine and norepinephrine act as a stimulator of sexual desire.[4][5] Flibanserin is a 5-HT1A receptor agonist and 5-HT2A receptor antagonist that had initially been investigated as an antidepressant.[6][7] Preclinical evidence suggests that flibanserin targets these receptors preferentially in selective brain areas and helps to restore a balance between these inhibitory and excitatory effects.[5][8] HSDD has been recognized as a distinct sexual function disorder for more than 30 years.[9]

ACCEPTORS: 1

DONORS: 1

ROTATION BONDS: 2

N+O: 5

Chiral Centers: 0

LogP: 4.7

LogS: -5.03

LIPINSKI: 4

Synonyms: Flibanserin;Bimt 17;3-[2-[4-[4-(Trifluoromethyl)phenyl]piperazin-1-yl]ethyl]-1H-benzimidazol-2-one

CAS:167933-07-5

MF:C20H21F3N4O

MW:390.4

EINECS:

Product Categories: Flibanserin Flibanserin

Usage And Synthesis: Flibanserin

MW: 340.47

CAS: 3733-63-9

MDL NUMBER: MFCD00869150

Smiles: OCCOCCN1CCN(CC1)C(c1ccccc1)c1ccccc1

ACCEPTORS: 2

DONORS: 1

ROTATION BONDS: 5

N+O: 4

Chiral Centers: 0

LogP: 2.53

LogS: -4.44

LIPINSKI: 4

Synonyms: 1-benzhydryl-4-(2-(2-hydroxyethoxy)ethyl)piperazine;decloxizine;DECLOXIZIN HYDROCHLORIDE;Decloxizine Base;decloxazine;2-[2-[4-(Diphenylmethyl)-1-piperazinyl]ethoxy]ethanol;UCB 1402;UCB-1402

CAS:3733-63-9

MF:C21H28N2O2

MW:340.45922

EINECS:

Product Categories:Pharmaceutical Intermediates Decloxizine

Chemical Properties:

CAS DataBase Reference: 3733-63-9(

CAS DataBase Reference: ) Decloxizine

Usage And Synthesis: Decloxizine

MW: 173.17

CAS: 18664-39-6

MDL NUMBER: MFCD00016845

Smiles: OC(=O)/C=C\c1ccc(cc1)C#N

ACCEPTORS: 2

DONORS: 1

ROTATION BONDS: 2

N+O: 3

Chiral Centers: 0

LogP: 1.61

LogS: -3.06

LIPINSKI: 4

Synonyms: 3-(4-CYANOPHENYL)ACRYLIC ACID;AKOS BAR-2475;4-CYANOCINNAMIC ACID;RARECHEM BK HD C008;cyanocinnamicacid;p-cyanocinnamic acid;3-(4-Cyanophenyl)propenoic acid;3-(4-cyanophenyl)acrylic acid (en)

CAS:18664-39-6

MF:C10H7NO2

MW:173.17

EINECS:242-484-8

Product Categories: 4-Cyanocinnamic acid

Chemical Properties: mp 245-248C

CAS DataBase Reference: 18664-39-6(

CAS DataBase Reference: )

Safety Information: Risk Statements 36/37/38 Safety Statements 26-36/37/39 4-Cyanocinnamic acid

Usage And Synthesis: 4-Cyanocinnamic acid